http://jid.oxfordjournals.org/content/204/suppl_3/S804.full
Abstract
In 2008, Reston ebolavirus
(REBOV) was isolated from pigs during a disease investigation in the
Philippines. Porcine reproductive and respiratory syndrome
virus (PRRSV) and porcine circovirus type 2 (PCV-2)
infections were also confirmed in affected herds and the contribution
of REBOV to the disease outbreak remains uncertain.
We have conducted experimental challenge studies in 5-week-old pigs,
with
exposure of animals to 106 TCID50
of a 2008 swine isolate of REBOV via either the oronasal or
subcutaneous route. Replication of virus in internal organs and
viral shedding from the nasopharynx were documented
in the absence of clinical signs of disease in infected pigs. These
observations
confirm not only that asymptomatic infection of
pigs with REBOV occurs, but that animals so affected pose a transmission
risk
to farm, veterinary, and abattoir workers.
